Omer Shaish was born and raised in Israel and has performed as a young actor at Habima National Theater and Beit Lessin Theater in Tel Aviv. In 2007 he moved to New York City and has graduated from The American Musical and Dramatic Academy.

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His theater credits include the Radio City Christmas Spectacular (Radio City, NYC), The VocaPeople (New World Stages, NYC) the US National Tour of Seussical, and the Israeli National Premier of Spring Awakening. Omer has performed as a vocalist in prestigious venues such as Lincoln Center, Radio City, ICC Center in Jerusalem, Toronto Center Of the Arts, and Auditorio Nacional in Mexico City. He also performed as a soloist at the Celebrity Fight Night (Florence, Italy), featuring Andrea Bocelli, George Clooney and Lionel Richie.

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Since 2015, Omer has been touring the world as a lead singer in the classical vocal trio Kol Esperanza, as well as his self-produced show My Broadway Shpiel. In 2022, he portrayed the role of Ilmarinen in the Kalevala Broadway concept album alongside Ramin Karimloo and Julia Murney.